ALREX is a C-20 ester corticosteroid with a low risk of elevated IOP1*
Ocular corticosteroids, like ALREX, are thought to block inflammation by inducing phospholipase A2 inhibitory proteins, called lipocortins, which prevent the synthesis of downstream inflammatory signaling mediators.1
PREDNISOLONE
Most ocular corticosteroids have a ketone at the C-20 position. When ocular metabolism occurs, some metabolites remain active.2-4
ACTIVE (LOTEPREDNOL ETABONATE)
The active ingredient in ALREX, loteprednol etabonate, has an ester at the C-20 position, allowing ocular esterases to break down the active corticosteroid into inactive metabolites1-4
INACTIVE (17β-CARBOXYLIC ACID)
After exerting its therapeutic effects, ALREX is converted into inactive metabolites, which may result in a lower potential for adverse events, such as increased intraocular pressure (IOP)1-4
*If ALREX is used for more than 10 days, IOP should be monitored.